World’s first-ever dengue vaccine gets green signal from WHO

Dengvaxia is the first ever vaccine against dengue that is counted among the most complex viruses. After the go-ahead from World Health Organization, it is now for the affected countries to take a call on its implementation

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New Delhi: The World Health Organization (WHO) has given its nod to the world’s first-ever vaccine for dengue fever, a potentially deadly mosquito-borne virus that threatens to infect close to half of the world’s population.

Known as Dengvaxia, the vaccine is the product of two decades of research by French-based Sanofi Pasteur. Four countries—Mexico, Brazil, El Salvador and the Philippines—have already licensed Dengvaxia, but the recommendation on April 14, 2017, will likely spur a host of other developing nations to follow suit at a time when climate change and urbanization is putting increasing numbers of people at risk from the mosquito-borne disease.

“In countries where dengue is endemic, it’s one of the most feared diseases. The trajectory globally is increasing at this point, it’s essentially a pandemic,” Dr In-Kyu Yoon, director of the Dengue Vaccine Initiative, an international consortium that has partnered with Sanofi, was quoted in the international press.

Unlike malaria, there is no established cure for dengue fever, which can cause severe nausea, bone pain, headaches, rashes, bleeding and even death. The virus can last for up to 10 days. About 390 million people are infected by dengue each year in some 120 countries, particularly in Southeast Asia, Latin America and Africa.

Scientists have been unable to develop a vaccine for dengue in part because the virus is so complicated. It has four strains, more than other deadly diseases such as polio and smallpox. If a person gets infected with more than one type of dengue, there is a greater chance of the virus of causing hospitalization or death.

Experts say that there have historically only been a few places where more than one serotype of dengue circulates at any given time, but urbanization has made it more common to have multiple serotypes in the same area.

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