Bayer Pharmaceuticals accelerates innovations for patients

New Delhi: At its annual Pharma Media Day 2023, Bayer presented the latest progress in the ongoing transformation of its pharmaceutical business focusing on accelerating innovative healthcare solutions for the benefits of patients and delivering long-term, sustainable business growth.

“The transformation of our Pharma business is progressing well. With bold investments in industry-leading technology platform companies, we have bolstered our R&D capabilities and strengthened our early development pipeline,” said Stefan Oelrich, Member of the Board of Management, Bayer AG and President of Bayer’s Pharmaceuticals Division. “We will specifically allocate resources to grow our oncology and cardiology businesses in the U.S. The implementation of our strategy aims to deliver new medicines to patients faster and drive sustainable growth across our key areas of focus.”

During this year’s Pharma Media Day 2023, Bayer showcased how its investments in strategic technology platforms accelerate its medical and digital innovations and will advance the company’s leadership ambitions in cardiology, oncology, and radiology. In addition, Bayer provided insights into its innovation strategy, comprising enhanced research and development (R&D) capabilities in key areas.

“Patient needs, precision therapies to address disease complexity as well as advances in science and technology are evolving rapidly. Therefore, we are evolving our R&D strategy and operating model to focus on differentiated, high-value breakthrough medicines,” said Christian Rommel, Member of the Executive Committee of Bayer’s Pharmaceuticals Division and Head of Research and Development. “Moving forward, we will focus our early research activities on core strategic areas: oncology, cardiovascular, neurology & rare diseases and immunology, where we believe we can make the biggest possible difference for the patients we serve.”

Delivering significant growth through a leadership position in oncology

The company has doubled its portfolio of oncology treatments over the past five years, with nearly one third of new molecular entities within Bayer’s development pipeline dedicated to fighting cancer, spanning all phases of clinical development. In particular, the company highlighted its plans to become a leader in the treatment of prostate cancer, the second most commonly diagnosed cancer in men.

“We are well placed to deliver on our commitment to bring innovative medicines to cancer patients,” said Christine Roth, Member of the Executive Committee of Bayer’s Pharmaceuticals Division and Head of the Oncology Strategic Business Unit. “Bayer has clear ambitions to become a top oncology company. We are investing in innovative treatments and modalities that have the potential to be transformative for a broad range of cancer patients, who currently have little or no treatment options.”

Bayer is advancing its oncology R&D efforts in three scientific areas that have the potential to address unmet needs in cancer patients. This includes targeted radiopharmaceuticals (specifically targeted alpha therapies), next-generation immuno-oncology and precision molecular oncology approaches. In these areas, the company is advancing truly first-in-class, highly innovative projects in its portfolio.

With recent major investments, Bayer has fortified its oncology innovation engine substantially. The new $140 million Bayer Research and Innovation Center (BRIC) facility, located in the center of thriving Boston-Cambridge, Massachusetts, is home to Bayer’s precision molecular oncology research group, fostering collaborations in this outstanding U.S. innovation hub, including with the Broad Institute of MIT and Harvard.

Vividion Therapeutics, which Bayer acquired for $1.5 billion, comprises a leading chemoproteomics platform capable of identifying previously unknown binding pockets in undruggable targets to generate first-in-class novel drug candidates in indications of high unmet medical need. This technology and the unique approach of an innovative arms-length operating model have the potential to accelerate the timelines to get assets into the clinic. The first two programs are addressing high profile cancer targets.

Developing the next generation of cardiovascular therapies

The short- to medium-term growth in the area of cardiovascular (CV) diseases will be driven mainly by by its existing assets.

Building on its strong late-stage projects, the company has set a clear directive towards precision cardiology, exploring innovative approaches across a diverse range of modalities, with the aim of pushing the boundaries of innovation for patients with cardiovascular diseases with high unmet needs and potentially reversing life-altering conditions. Complementing in-house expertise with external collaborations remains a vital part of Bayer’s strategy to expand its R&D expertise and develop robust cardiovascular therapies, with the goal of addressing high unmet medical needs across broad indications, including specialty cardiology and rare indications. Through Asklepios BioPharmaceutical Inc. (AskBio), Bayer is developing a gene therapy as a potential new approach for treating congestive heart failure. With the acquisition of AskBio, Bayer gained access to an industry-leading gene therapy platform with demonstrated applicability and world-class manufacturing facilities. Beyond congestive heart failure, AskBio is also currently advancing four clinical-stage and a number of preclinical candidates addressing medical need indications across a diverse set of diseases such as Parkinson’s disease, Pompe disease and Huntington’s disease.

Bayer’s advancements in cardiovascular disease are enabled by digitalized, decentralized and more diverse clinical trials, as well as partnerships on industry-leading sources of data, such as the Accelerating Medicines Partnership in Heart Failure and the Broad Institute’s Precision Cardiology Laboratory. These initiatives are helping to accelerate the discovery of new molecules and bring new treatments to patients that need them.

“Cardiovascular diseases can have a significant impact on patients’ lives. We are advancing highly innovative projects in our portfolio to address patients’ high unmet medical needs and shape the future in cardiology,” said Christian Rommel, Member of the Executive Committee of Bayer’s Pharmaceuticals Division and Head of Research and Development. “The number of innovative approaches and novel modalities in our portfolio will triple in future. With those we will be able to target pathologies and disease mechanisms that were not druggable before.”

Leveraging digital innovation to support diagnosis and drug discovery

Bayer is implementing its innovation strategy in radiology, with a key focus on digital medical imaging and artificial intelligence (AI). The medical imaging AI market is the fastest growing segment within the global radiology industry. The estimated compounded annual growth rate is more than 26 percent reaching $1.36 billion in sales by 2026. A cornerstone of Bayer’s ambition is its recently launched medical imaging platform, which delivers access to digital applications, including those powered by AI. It provides an ecosystem of third-party and Bayer products to deliver disease-oriented solutions for radiologists and their teams. The platform is designed to support healthcare professionals at various stages of their work, from diagnosis through treatment of their patients.

To bolster its position in the medical imaging AI market, Bayer recently acquired the global strategic imaging AI platform and solutions provider Blackford Analysis Ltd, which will operate under Bayer’s well established “arm’s length” operating model. Utilizing Blackford’s and Bayer’s combined expertise in healthcare technology, this acquisition fosters Bayer’s engagement to drive digital innovation in healthcare, with the aim to deliver true value to radiologists and their teams for the benefit of their patients.

“Building on a deep medical expertise across a multitude of diagnostic and therapeutic areas, Bayer is a leader in key radiology segments with a comprehensive portfolio that generated close to 2 billion euros sales in 2022,” said Gerd Krueger, President Radiology, Bayer. “Expanding our offerings into the field of AI further advances our strong position in this market. It follows our mission to deliver disease-oriented solutions for patients and their physicians. The transformative expansion of our radiology business is a key element of Bayer’s accelerated digital transformation, which strategically leverages data science and advanced analytics across the value chain.”

Bayer is investing to leverage the power of data and rapidly evolving technologies such as artificial intelligence throughout the entire pharma value chain, from discovery to production. The company is partnering with technology leaders such as Google Cloud and biotech leaders such as Recursion Pharmaceuticals, Inc. to access new areas of innovation. In addition, Bayer has built up extensive in-house expertise to transform its development, manufacturing and medical operations to better serve the needs of patients, healthcare professionals and healthcare systems with relevant innovative solutions. Bayer works on leveraging all the possibilities of the technologies while fully integrating all regulatory and bioethical requirements.