Medanta conducts SAARC’s first youngest blood group incompatible kidney transplant

The development is being seen as a ray of hope for patients unable to find same blood group match for kidney transplant

New Delhi: In a major breakthrough in kidney transplant, doctors at Medanta-the Medicity conducted an ABO incompatible kidney transplant on the youngest child in SAARC region. The team of doctors led by Dr. Shyam Bansal, Associate Director, Kidney Institute, Dr. Sidharth Sethi, Consultant, Pediatric Nephrology and Pediatric Renal Transplant and Dr. Prasun Ghosh, Associate Director-Renal Transplant conducted the path breaking surgery on a three year old child weighing 10 kg who by birth had a condition called ‘reflux nephropathy’ in which the urine tends to go back to the kidneys.
Pratyasha, had chronic kidney failure at the age of 3 year. She required an early kidney transplant, but there were no blood group compatible donors. An attempt was made to swap the donors with other families and for cadaveric donation list, but nothing materialized. After six months of desperate search, the Kidney and Urology Institute at Medanta hospital planned to take mother as a donor which was a blood group incompatible transplant. Child was B+ and mother was A+.
Right to left - Dr. Sidharth Sethi, Dr. Shyam Bansal & Dr. Prasun GhoshSpeaking on the occasion, Dr. Sidharth Sethi, Consultant, Pediatric Nephrology and Pediatric Renal Transplant, Medanta, The Medicity, said, “We had already done India’s first Pediatric blood group incompatible kidney transplant on a 12 years-old child in October 2014. The major risk of blood group incompatible transplant is hyperacute rejection (kidney may stop working the same day of transplant). Looking at the criticality of the surgery, we designed a protocol with immunoadsorption column to remove the antibodies, and then conducted the transplant on 5th April. Since, mother had a different blood group, the child received renal transplant with mother as the donor, with a designed desensitization and immunosuppressive protocol.”
“The child responded amazingly post-transplant, and is doing great with stable graft function. This is the first time in India that immunoadsorption protocol has been used in a small child. This is also the SAARC’s youngest blood group incompatible kidney transplant. The child is currently completely normal, and leading a normal life.”Further added, Dr. Sidharth Sethi, Consultant, Pediatric Nephrology and Pediatric Renal Transplant, Medanta, The Medicity.
The shortage of cadaveric donation (donation after death) for transplant is a global problem. Statistics suggest that about 2,20,000 people in India are waiting for a kidney transplant; out of which, only 7,000 of them are able to receive a transplant every year. Only 1 out of 30 people who need a kidney transplant receives one. The breakthrough surgery conducted by doctors at Medanta- the Medicity will prove beneficial for such people and give them an option to undergo kidney transplant even if the blood groups does not match.