Nearly 55 million people are suffering from Chronic obstructive pulmonary disease (COPD) in India. They are many reasons for COPD and one of the most important reasons is alpha 1 antitrypsin (AAT) deficiency. This hereditary disorder causes the alpha-1 antitrypsin protein to be reduced or missing from the blood. In this condition, the abnormal structure prevents the protein from getting out of liver cells, where they are produced to move towards the lungs where they are to be utilized.
AAT protein is necessary for healthy lungs, and the body uses it to protect the lungs from damage. If a person has low or no levels of AAT, their lungs may get severely damaged. Recent studies have shown that AAT deficiency leads to lung cancer, asthma, osteoporosis, and liver cancer.
In this backdrop, two Hyderabad based researchers observed many problems related to lung disorders while doing research in lung disorders like chronic obstructive pulmonary disease (COPD) and lung cancer. Dr T Sreelatha and Mr Vydyanath while exploring the options to treat the same, came to know about the AAT therapy and its advantages. However, when they came across the expensive price tag around the existing options, they decided to focus on reducing the cost of AAT therapy for the last two years.
They initiated their startup, Sree Therapeutics at the Bio-NEST incubator hosted in University of Hyderabad, with the help of BIRAC-Biotechnology Ignition Grant (BIG) programme through IKP as the BIG partner.
Explaining the idea behind their research, Dr Sreelatha says, “Each patient requires 5 gm of AAT in a week and 1 gm AAT costs approximately the US$ 400. The main reason behind the expensive cost is antibody-based resin using for purification of AAT. We thought to reduce the production cost by changing the purification method.”
She and her team searched many ways in this regard and came out with novel purification method i:e; dual ligand affinity based resin. This method is able to reduce the cost by 10 folds compared with the original cost.
“Our key focus is to develop novel affinity-based methods for purification of therapeutic proteins with affordable price,” adds Dr Sreelatha.
Overcoming initial challenges
Just like other biotechnology startups, funding was a major problem for Sree Therapeutics too. However, this problem of the company was solved in part by BIRAC through IKP (BIG funding).
Recollecting the same, Dr Sreelatha explains: “We incubated at Bio-NEST, University of Hyderabad. Funding and scientific network are very essential for any startup. We received exceptional support from IKP. Listening to Deepanwita madam is truly inspirational and we are lucky to be in Hyderabad. We are very happy to be having such a great supporter around us. In every step, the IKP team is helping us a lot. I am very thankful to IKP, Bio NEST- UoH and BIRAC team.”
