By Ratneshwar Thakur
New Delhi: In our day to day life, global positioning system (GPS) helps us quickly determine our location and guides us to preferred destination. Similarly, in living cells, molecules like proteins have their own positioning system which guides cells to coordinate their functioning and ensures response. There is constant cross-talk among molecules in different compartments of cell through such a positioning system.
Indian researchers are studying this positioning system in proteins like RDGB which ferry and move lipid molecules to maintain homeostatic levels of lipids in plasma membrane. An understanding of how molecules like RDGB control lipid composition may help to get an insight into complications that lead to cancers and neurodegenerative diseases.
A team of researchers led by Dr Padinjat Raghu at National Centre for Biological Sciences, Bangalore have shown that signals present within RDGB protein determine if it will remain in a specific compartment of the cell for it to function normally. “This is important since in the absence of such localization, cellular function of this protein will be compromised,” researchers say in their study published in Journal of Cell Science.
“RDGB is known to localize at a specific location in the cell to maintain lipid composition of two closely situated membranes by transferring lipids from one compartment to the other. We want to understand how this process might be regulated,” pointed out Rajan Thakur, co-author of this study. The work has been done in fruit fly which has a simpler genome makeup and shares much of organizational principles of human cells.
Cells have thousands of molecules like proteins, lipids and carbohydrates and others, and still every function is perfectly executed with respect to time, distance and their location. The new study explains that though different cellular structures perform specialized functions in seclusion, they do exchange information with each other to shape signaling output of the cell.
