India’s Evergreen Vaccine Story

India's biotechnology industry is positioned to become a significant engine of the Indian economy, writes Mrs. Suchitra Ella Managing Director, Bharat Biotech International Limited  

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Suchitra Ella, Managing Director, Bharat Biotech.
About Author: Sucharita Ella co-founded Bharat Biotech with Dr Krishna Ella in 1996. With experience in customer operations, finance, marketing and business development, Mrs. Ella is a strong pillar of support and guidance at Bharat, overseeing a wide range of operations in the company. She is also the Chairperson of CII – Southern Region and Indian Women Network. Several awards have been conferred on her including Padma Bhushan-India’s 3rd highest Civilian Award.

Did you know that ‘vaccine’ was chosen as the word of the year in 2021, by the Merriam-Webster dictionary? And quite rightly so, for over two years, COVID-19 occupied a large portion of our lives. And if you stop to think about it, the vaccine, along with the widely effective immunization drives, brought normalcy back into our lives. Life is returning to whatever the new normal will be when COVID-19 transitions to an endemic disease. However, the pandemic caused earth-shattering changes in the biotech industry that will have a long-term effect on vaccine development schedules. But India proved its mettle when the world witnessed India’s vaccine developing and manufacturing prowess.
SARS-CoV-2 heralded the world into a pandemic of unpredictability. Everyone stood dejected, hoping for a vaccine to miraculously save us all. Indian vaccine makers, testers, and regulators have altered how vaccines are created, tested, and evaluated, giving them the confidence to use new technology to treat a variety of diseases and to try out novel ways to inoculate. The three major interventions in the biotech space are vaccines, therapeutics, and diagnostics, that are indispensable to public health to prevent diseases, yet low- and middle-income countries (LMICs) in particular have had insufficient access.
“While the COVID-19 narrative continues to transform the world, Bharat Biotech has delivered vaccines globally.”
I can still vividly remember how people would lose hope when informed individuals and the media prophesied that India wouldn’t be able to immunize its citizenry. Since Indians banded together to fight for a brighter, healthier future, India is today seen as the world’s saviour in developing cost-effective vaccines. We, at Bharat Biotech, persevered and innovated to rise to the challenge, creating COVAXIN®, India’s first indigenous vaccine for COVID-19, in just nine months, whereas it took more than 30 years to develop an effective vaccine for rotavirus. The road to success was undoubtedly not an easy one, with over 350 million doses being administered under Government of India’s COVID-19 vaccination programs and several million doses being exported.
The Biotech Industry Scenario
While the COVID-19 narrative continues to transform the world, Bharat Biotech has delivered vaccines globally for hepatitis B, influenza, H1N1, rotavirus, Japanese encephalitis, rabies, chikungunya, zika, and the world’s first tetanus-toxoid conjugated vaccine for typhoid. Bharat Biotech has delivered close to 5 billion doses of vaccines.
Over the past 26 years, the life sciences sector in India has grown from a nascent one to a burgeoning one. I had no idea that when my husband, Dr. Krishna Ella, and I founded Bharat Biotech in 1996, we were sowing the seeds for the nation’s biotechnology revolution. India is the third-largest biotechnology destination in the Asia Pacific area and one of the top 12 most popular biotechnology locations worldwide. India’s biotechnology sector is growing as a result of increased demand on a national and global level. Initiatives like ‘Atmanirbhar Bharat’ and ‘Make in India,’ are helping increase domestic demand, however, the success of Indian vaccines and biopharmaceuticals has helped enhance demand for these products internationally. India is a top location for contract production and clinical trials and exports vaccines to more than 150 nations. Companies are utilizing generics and biosimilars to control healthcare costs, and India has positioned itself as a centre to provide accessible, inexpensive healthcare that is inclusive of all people.
Research & Development
R&D must come first for every business, followed by manufacturing and development, and only then should marketing be considered. R&D, however, is the most underutilised sector in India. The Indian biotech industry has been consistently producing affordable generic drugs and vaccines with the help of our resources, geographic placement, and skilled workforce. The considerable growth in that market has proven to the world that India can produce quality drugs that are economically priced.
We at Bharat Biotech now take it to the next step by continuing our focus on investing in Research and Development that can take us to a Global standing in the Pharma industry in terms of innovation, research, development, and testing.
Research is also underway to create vaccines for Chikungunya, rotavirus, malaria, liquid rabies and Staphylococcus Aureus. We continuously monitor emerging diseases and upgrade our research portfolio to help patients in need.
“Over the past 26 years, the life sciences sector in India has grown from a nascent one to a burgeoning one.”
Public-Private Partnership
The development of additional public-private partnerships (PPP), which have been vital in developing science and innovation in India, is another important goal for the vaccine industry. The effectiveness of the PPP strategy has been demonstrated by vaccines for the rotavirus, typhoid fever, and COVID-19. The PPP between the Department of Biotechnology, GOI, NIH, CDC, PATH, the Gates Foundation, Society for Applied Studies, Bharat Biotech, and other knowledge partners like the AIIMS and Stanford University to develop a rotavirus vaccine and the development of an indigenous COVID-19 vaccine is a great example of social innovation.
What the Future Holds
As a forerunner in the biotech space, I firmly believe that we need to lose the fear of failure and endeavour to forge ahead to build a legacy of becoming a citadel of vaccine manufacturing and development. India’s biotechnology industry is positioned to become a significant engine of the Indian economy as one of the nation’s fastest growing knowledge industries. With next-generation, tailored, and reasonably priced medications, it plays a crucial part in enhancing the health of the country. It is up to us as a country to make wise and practical investments in order to reap the rewards of this technology of hope for its billion citizens. Biotechnology has the potential to be transformative and far-reaching.
India might get a sizable value share of the international life sciences market by concentrating on cutting-edge innovation. India must move quickly to seize this significant potential, and the government must facilitate this process by establishing a favourable physical, financial, legislative, and regulatory ecosystem. The scientific community, the business sector, and the government may all work together to achieve common goals in order to advance Indian biotechnology.
Way Forward
For public health to develop, we need to collaborate with organizations dedicated to science and inquisitive minds. By working with the larger ecosystem, we are better equipped to appreciate the disease patterns that cause mortality and morbidity across emerging nations. We should publicly share our research with collaborators in order to advance scientific understanding. I can assure that Bharat Biotech’s passionate scientists and production experts are dedicated to finding technological solutions to the problems affecting public health. We seek to lead innovation in biotechnology in order to lead the fight against disease with a focus on emerging markets. We will continue to do different things and do things differently! Let’s collaborate so that India has adequate medical facilities.

**This article was first published in the January 2023 edition of the BioVoice eMagazine. The views expressed by the author are her own.